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High dose intravenous (IV) thiamine supplementation (500 mg thiamin dissolved in 100 mL normal saline) led to a reduction in the frequency of migraine attacks (20)

Piezo1 expression in cortical astrocytes is induced by LPS (Velasco-Estevez et al., 2020), and LPS exposure can upregulate Piezo1 expression in a modest proportion of astrocytes (approximately 25%) (Velasco-Estevez et al., 2020)

It can draw water into the skin to improve hydration and also plays a role in the skin's natural moisturizing factor (NMF) in the form of sodium lactate